Difference Guillain barre syndrome , Myasthenia gravis and Motor neuron disease



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GBS = Guillain Barre Syndrome ,MG = Myasthenia Gravis and MND = Motor Neuron Disease

 

                                                GBS                                        MG                                                          MND

 

 

Weakness                             Yes                                          Yes                                                                  Yes

 

Reflexes                                 Absent                                    Present                                    May be increased                                                                                                                                               amyotrophic lat sclerosis

Distribution                      Ascending +                           Eyes + CN’s                                    Asymmetrical

                                                Symmetrical

 

Progression                          Acute -> recovery               Relapsing                                       Progressive

 

Fatigue                                  No                                           Yes                                                                   No

(characteristic)

 

Fasciculations                      No                                           No                                                                Yes

 

Increased CSF Protein       Yes                                          No                                                               No

 

UMN signs                            No                                           No                                    May be – amyotrophic

lateral sclerosis

 

Sensory features         Often dysesthesia + pain          No                                                                  No

 

Pain                                        Often                                       No                                                                       No

 

Delayed nerve                     Yes                                          No                                                                       No

conduction

 

Fade + post tetanic

count facilitation             No                                           Yes                                                                  No

 

Jitter on EMG                       No                                           No                                                               Yes

 

Response to

Anticholinesterase             No                                           Yes                                                              No

 

Response to plasma-

pheresis                               Possible                                 Yes                                                                  No

gbs

 

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